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Important side effects to look out for

Important side effects to look out for

You must get urgent medical help if you have any of the following symptoms.

These are rare (may affect up to 1 in 1000 people). You may be having a serious allergic reaction if:

  • You have difficulty breathing.
  • Your face or throat swell.
  • Your skin develops a severe rash.
  • You experience blistering of the skin, mouth, eyes and genitals or your skin peels.
  • Blood spots near the injection site which could develop into a purple blister surrounded by red inflamed skin.

Common side effects (may affect up to 1 in 10 people)

• Bleeding (haemorrhage).

• Anaemia. Reduction in red blood cells which can make the skin pale and cause weakness and breathlessness.

• A pooling of blood in tissues which may result in the skin appearing dark in colour, similar to a large bruise.

• Pain, itching, bruising or bleeding, redness, swelling, nodules or hard lumps under your skin where the injection was given.

Uncommon side effects (may affect up to 1 in 100 people)

• Changes in your blood test results. There may be a change in the clotting cells (platelets) in your blood. These tests will return to normal after innohep is stopped.

• An allergic reaction. You may be sensitive to one of the ingredients in this medicine.

• Bruising, red or purple spots under your skin.

• Some blood tests may also show a change in the way your liver is working. These tests will return to normal when innohep is stopped.

• An itchy red rash with heat and swelling on your skin (dermatitis).

• Rash.

• Itchy skin.

Rare side effects (may affect up to 1 in 1000 people)

• Your blood may form more harmful clots. A drop in the number of clotting cells (platelets) in your blood may give you these symptoms. Your doctor can explain this more.

• Changes in your blood test results. The amount of potassium may be increased. This is more likely to happen if you have severe kidney problems or diabetes. Your doctor can explain this more.

• Hives.

• Your bones may weaken and break more easily. This is known as osteoporosis and has been seen in patients using heparin for a long time.

• Prolonged, painful erections in men.

Contact your doctor if you…

  • Notice any symptoms that are consistent with a blood clot in your leg or lung (See also: “Warning signs for DVT & PE”Believe that you may have become pregnant since you began your treatment
  • Suffer an injury, especially to your head, eyes or joints
  • Bleed a lot after a cut or operation
  • Bleed from your nose or gums for more than five minutes
  • Have abnormally heavy bleeding during menstrual periods
  • Vomit blood or material that looks like coffee grounds
  • Pass red or brown urine or produce black tarry stools (faeces)

Reporting of side effects

If you get any side effects, talk to your doctors, pharmacist or nurse. This includes any possible side effects not listed in the package leaflet. 
  • UK: You can also report side effects directly via the Yellow Card Scheme at www.mhra.gov.uk/yellowcard 
  • Ireland: You can also report side effects directly via HPRA Pharmacovigilance, Earlsfort Terrace, IRL-Dublin 2 Tel: +353 1 6764971; Fax: +353 1 6762517. Website: www.hpra.ie; E-mail: medsafety@hpra.ie 
By reporting side effects you can help provide more information on the safety of this medicine. 

You can find further information about using innohep® in the Package leaflet available for both UK and IE here: